(Selected) research & publications

RECOVERY platform trial evaluating sotrovimab for hospitalised COVID-19.

AERATOR observational study identifying clinical and physiological factors associated with respiratory aerosol generation.

Observational IL-6 profiling plus IL6R Mendelian randomisation supporting IL-6 inhibition as a therapeutic strategy in pleural infection.

Genetic analysis supporting IL-6 inhibition as a potential therapy for severe influenza.

Technical evaluation of methods for detecting non-linear genetic effects in epidemiological data.

Review of the opportunities and challenges of applying genetic methods to potential infectious disease targets.

Methodological study exploring why IV analyses can generate biased estimates in observational antibiotic studies.

Methodological work identifying major problems with a widely used genetic method for non-linear effects.

Extended genetic analysis of IL-6 signalling to tuberculosis across multiple ancestries.

Identified novel opposing effects of ERAP2 genetic variation on respiratory infection versus autoimmune disease.

Identified the protective observational role of small HDL particles in sepsis, but found genetic analyses inconclusive.

Combined observational analyses and Mendelian randomisation to assess iron status biomarkers and sepsis risk.

Identified potential therapeutic benefit of IL-6 inhibition in sepsis using Mendelian randomisation.

AERATOR quantitative data suggesting facemask ventilation is not a high aerosol-generating procedure compared with cough/breathing baselines.

AERATOR work showing that patient events (not scope insertion/removal per se) drive aerosol peaks during OGD.

AERATOR measurements during spirometry/peak flow/FENO; supports de-listing standard lung function tests as AGPs with appropriate mitigation.

Multicentre RCT-derived analysis evaluating blood culture time-to-positivity as a mortality prognostic marker.

Key publication from the AERATOR study quantifying aerosol generation from oxygen systems.

AERATOR study showing common pleural procedures are not associated with high aerosol generation.

AERATOR-led comment/debate challenging AGP classifications using emerging clinical aerosol data.

Identified potential benefit of aspirin in pneumonia, leading to the ASPECT randomised trial.

RECOVERY platform trial showing improved outcomes with tocilizumab in hospitalised COVID-19 with hypoxia and systemic inflammation.

Bayesian re-analysis of RECOVERY convalescent plasma results, highlighting subgroup-dependent posterior probabilities of benefit.

Described potential positive effect of COVID-19 vaccination on long-COVID symptoms.

First UK description of long-COVID outcomes in hospitalised patients.

Systematic review/meta-analysis showing early warning scores have limited accuracy for sepsis mortality prediction.